St. Louis County is located in the far eastern portion of the U.S. state of Missouri. It is bounded by the city of St. Louis and the Mississippi River to the east, the Missouri River to the north, and the Meramec River to the south.
St. Louis is an independent city and major U.S. port in the state of Missouri, built along the western bank of the Mississippi River, which marks Missouri's border with Illinois. The city had an estimated 2018 population of 308,626 and is the cultural and economic center of the St. Louis metropolitan area (home to nearly 3,000,000 people), which is the largest metropolitan area in Missouri, second-largest in Illinois (after Chicago), the 22nd-largest in the United States.